Pdf toxicological studies on albino wistar rats coadministered with. A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and kept for scientific research. The wistar rat, wistar hannover wistar han rat, and wistar unilever wu rat are outbred rat strains, while the wistar kyoto and wistar furth rats. Repeated subcutaneous administrations of krokodil causes. Differential effects of h2 receptor antagonists on male. The age at detection of first glycosuria has varied from 48 to 120 days, with a mean of 67 days. Evaluation of the effects of fasting on fertility in adult male wistar rats. Wistar institute in philadelphia, giving rise to the ubiquitous presentday wistar strain of rats festing, 1979. This article is an openaccess article which was selected by an inhouse editor. If the image photo is included then we should be careful which pages redirect to this article. Adult wistar rats n 18 females and 26 males were obtained from charles river and maintained on teklad 2020 phytoestrogenfree diet, then paired and monitored for the presence of a sperm plug, which was designated gestational day gd 0.
The survey, performed at the 10th generation of backcrossing, showed that wistar fatty rats fafa, a congenic strain of wky, developed obesity and obesityrelated features, such as hyperinsulinemia and hyperlipemia, in the same manner as zucker fatty rats. Evaluation of immune response after moderate and overtraining. Ratmouse default values rat default values subchronic study chronic study weaning bw water intake water factor. Our journal provide immediate free access to the full text of articles in html format. Journal of physiology and pathophysiology evaluation of.
A biodistribution study of y in male and female wistar rats was carried out in whole blood, liver, kidneys, intestine, heart, brain, lungs and spleen after 28 days of repeated oral treatment. This is because adobe, the original creator of the pdf format, actually still owns. Animals were kept under standard laboratory conditions 12 hr12 hr. The development of todays laboratory rat has been essentially an american initiative and the great majority of the strains of these animals that are presently in use throughout the scientific world have originated in the usa. This is in addition to the longest survival rate, lower bodyweight compared to sd rats, and lower tumor incidence compared to sd and f344 rats. While less commonly used for research than mice, rats have served as an.
To see the toxicopathological changes after multiple exposure to acetamiprid. As controls for the shr, most workers have used normotensive descendants of wistar rats from the colony in kyoto from which the shr strain was derived wistar kyoto rats. The spontaneously hypertensive rat shr initially bred in kyoto is the most widely studied animal model of essential hypertension. Immune system, moderate exercise, overtraining exercise, rat, th1. The wound healing effects of aqueous leave extracts of. Journal of medicinal plants research protective effects. The pilot study first phase used 16 adult male wistar albino rats rattus norvegicus weighing 300350 g, approximately 3 months of age, divided into four groups of 4 rats. The zucker fatty rat as a genetic model of obesity and hypertension pdf. Not all people looking for information on wistar rats are looking for information on lab rats. The aim of this study was to evaluate the effects of a diet containing gm soybean meal rur on male and female wistar rats. Comparative study of toxicological assessment of yttrium. The aim of our study was to analysed and evaluate the effects of buckthorn on nephroangiosclerosis wistar rats. To this end, we developed a cx3cr1dtr transgenic wistar rat with a diphtheria toxin receptor.
A new genetically obesehyperglycemic rat wistar fatty. Therefore, dexamethasoneimmunosuppressed wistar rats were studied during recovery from p. Aged munich wistar mw rats, like some other rat strains, develop some features characteristic of aging humans 1618 in that. Differential effects of aging on fluid intake in response. The methanolic extract of sargassum muticum mesm plays a hepatoprotective role in streptozotocin. Chronic inhalation exposure of wistar rats and two different strains. The animals were made available in the central animal house, gsvm medical college, kanpur, uttar pradesh, india. Experimental model of heterotopic ossification in wistar rats. Biochemical and histopathological studies on female and.
The development of todays laboratory rat has been essentially an american initiative and the. Pdf the reproductive toxicity of mequindox in a two. The one problem is that there arent very many free pdf editors. Hepatoprotective potential of sargassum muticum against. Toxic effect of lead on kidney function in rat wistar f. Male and female f344ntac rats and b6c3f1n mice were administered tetrabromobisphenol a purity of greater than 99% in corn oil by gavage for 3 months, and male and female wistar han crl. Adequate studies have been done using proton pump inhibitors and h2receptor antagonist and only few studies for cytoprotective and gastric acid secretions have been done in nigeria. Panchala, a department of pharmacology, institute of pharmacy, nirma university, sarkhej. Histopathology of skin and kidney of rat neonates showed marked damage. The body weights, food consumption, hematology, serum biochemistry, organ weight, and histopathological examination were compared between rats. A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and.
Since oxidative stress is implicated in the pathogenesis of liver diseases, this study was carried out to evaluate the hepatoprotective, hematoprotective and hypolipidemic effects of pleurotus ostreatus oyster mushroom in carbon tetrachloride ccl4 induced liver injury in wistar rats. Effects of nori and wakameenriched meats with or without. Spontaneous nonthymic t cell lymphomas in young wistar. Biochemical evaluation of silver nanoparticles in wistar rats. Wist hannover wistar rat is an extremely wellcharacterized strain worldwide, showing stable control data in oncogenicity studies over the last 25 years. Differential effects of h2 receptor antagonists on male reproductive function and hepatic enzymes in wistar rats aprioku js1, ibeachu c2, amahtariah fs3 1. The wistar bloodline has contributed more strains of rats. The wistar bloodline has contributed more strains of rats than any other line. Anticataractogenic effect of hesperidin in galactoseinduced cataractogenesis in wistar rats. Pdf induction of haematological and lipid profile changes by. While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion. These rats have been used extensively in physiological.
Adult wistar rats n 18 females and 26 males were obtained from charles river and maintained on teklad 2020 phytoestrogenfree diet, then paired and monitored for the presence of a. Anticataractogenic effect of hesperidin in galactose. En als het al om outbred wistars zou gaan, dan is het zo dat er enorme. Therefore, the aim of the current study was to screen the sap of m. Wistar rats were exposed for 2 yr to diesel engine exhaust, carbon black printex 90, degussa, fr. Variation in normal sodium, potassium, and calcium levels in. For instance, wistar rats were more susceptible to chronic stressinduced periodontitis than lewis rats. Clinical chemistry reference database for wistar rats and c57bl6 mice olaf boehm1,a, berndt zur2,a, alexander koch1, nguyen tran1, rainer freyenhagen1, matthias hartmann3 and kai zacharowski1,b. The laboratory rat, like its wild counterpart, is an extremely intelligent animal, probably more so than the other rodents commonly used for biomedical research. The folkloric claim of musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. We show evidence that agnps administration to wistar rats altered some biochemical parameters. Thirty male wistar rats, adult weighing between 120g and 250g were distributed as.
Glial remodeling enhances shortterm memory performance in. The males were then removed and the dams were housed individually. Clinical chemistry reference database for wistar rats and c57bl6 mice olaf boehm1,a, berndt zur2,a, alexander koch1, nguyen tran1, rainer freyenhagen1, matthias hartmann3 and kai zacharowski1,b, 1department of anaesthesiology, heinrich heine university medical school, d40225 du. Aoues 2 1departement of biotechnology, faculty of sciences, university of mostaganem 27000, algeria. Toxic effect of lead on kidney function in rat wistar. Variation in normal sodium, potassium, and calcium levels in wistar albino rats. In this study, we therefore aimed to determine how microglia contribute to shortterm memory in healthy adults. Ninetysix wistar rats 48 males and 48 females were used and grouped into. Biomarker responses serum biochemistry in pregnant female. Most are derived from the albino wistar rat, which is still widely used. The laboratory rat handbook of experimental animals.
Wistar han list of studies wistar han rats species strain sex route vehicle chemical rats wistar han male and female gavage corn oil pentabromodiphenyl ether mixture de71 technical grade rats wistar han male and female gavage corn oil tetrabromobisphenol a rats wistar han male and female gavage water green tea extract rats wistar. Therefore this work studied the cytoprotective and gastric acid secretory effects of rabeprazole, ranitidine, omeprazole and cimetidine in wistar rats. A new, spontaneously diabetic syndrome has been recognized in nonobese outbred wistar rats of both sexes. In the present study virgin wistar female rats served as experimental animals. Nephroprotective effect of sonchus oleraceus extract. The clinical research in past decade has reported that most secondgeneration antipsychotics sgas can cause serious metabolic derangement, which substantially increases the risk for type ii diabetes mellitus.
Evaluation of the effects of fasting on fertility in adult. The aim of this study is to scientifically determine if the aqueous leave extracts of azadirachta indica has wound healing abilities. The wistar kyoto wky rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptompresenting depressive patients. Effects of nori and wakameenriched meats with or without supplementary cholesterol on arylesterase activity, lipaemia and lipoproteinaemia in growing wistar rats volume 106 issue 10.
Laboratory rats introduction origin and development. Differences in the stress response of outbred wistar rats and inbred lewis rats have been reported earlier. The phytochemical screening was carried out on the methanol extract. Twenty male wistar rats two groups of 10 control and 10 experimental rats. This study was conducted to determine the mechanisms implicated in the beneficial effects of apple polyphenols aps against diet. Research open access metabolic syndrome markers in. Pdf toxicopathological changes on wistar rat after multiple. Antidiarrhoeal activity of musa paradisiaca sap in wistar rats.
Male wistar rats were randomly divided into control. Miyajima hikari branch, drug safety evaluation laboratories. Wistar rats male, 34 months, 250300 g were housed six animals per cage. He later established wistar institute in philadelphia that will have a major role in the development of the rat as an important laboratory animal similar to the impact the jackson laboratory had on the development of the laboratory mouse. Authors are also permitted to selfarchive their manuscripts. International journal of toxicology differences in rat. Roundup ready became the most cultivated genetically modified gm crop in the world. Clinical chemistry reference database for wistar rats and. Pdf toxicological studies on albino wistar rats cotreated with. Twenty male wistar rats two groups of 10 control and 10 experimental rats of average weight 150200g were used for this study. The rats were divided into five groups of six rats. The fa gene was transferred from the zucker rat m strain to the wistar kyoto wky rat. Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus dm.
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