While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion. Therefore, the aim of the current study was to screen the sap of m. The laboratory rat, like its wild counterpart, is an extremely intelligent animal, probably more so than the other rodents commonly used for biomedical research. While less commonly used for research than mice, rats have served as an. Effects of nori and wakameenriched meats with or without. Evaluation of immune response after moderate and overtraining. Miyajima hikari branch, drug safety evaluation laboratories. Chronic inhalation exposure of wistar rats and two different strains. Comparative study of toxicological assessment of yttrium.
Adult wistar rats n 18 females and 26 males were obtained from charles river and maintained on teklad 2020 phytoestrogenfree diet, then paired and monitored for the presence of a sperm plug, which was designated gestational day gd 0. Our journal provide immediate free access to the full text of articles in html format. Biomarker responses serum biochemistry in pregnant female. Journal of medicinal plants research protective effects.
Differences in the stress response of outbred wistar rats and inbred lewis rats have been reported earlier. Repeated subcutaneous administrations of krokodil causes. Toxic effect of lead on kidney function in rat wistar f. Differential effects of h2 receptor antagonists on male reproductive function and hepatic enzymes in wistar rats aprioku js1, ibeachu c2, amahtariah fs3 1. Pdf the reproductive toxicity of mequindox in a two. A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and kept for scientific research. Ninetysix wistar rats 48 males and 48 females were used and grouped into.
We show evidence that agnps administration to wistar rats altered some biochemical parameters. The development of todays laboratory rat has been essentially an american initiative and the great majority of the strains of these animals that are presently in use throughout the scientific world have originated in the usa. Wist hannover wistar rat is an extremely wellcharacterized strain worldwide, showing stable control data in oncogenicity studies over the last 25 years. Variation in normal sodium, potassium, and calcium levels in wistar albino rats. Therefore, dexamethasoneimmunosuppressed wistar rats were studied during recovery from p. The development of todays laboratory rat has been essentially an american initiative and the. Antidiarrhoeal activity of musa paradisiaca sap in wistar rats. The wistar kyoto wky rats were originally bred as normotensive controls for the spontaneous hypertensive line shr rats. The laboratory rat handbook of experimental animals. The wound healing effects of aqueous leave extracts of. The aim of our study was to analysed and evaluate the effects of buckthorn on nephroangiosclerosis wistar rats. Differences in stressinduced modulation of the auditory.
Wistar institute in philadelphia, giving rise to the ubiquitous presentday wistar strain of rats festing, 1979. Immune system, moderate exercise, overtraining exercise, rat, th1. The wistar kyoto wky rat strain demonstrates endogenous hormonal and behavioral abnormalities that emulate many of those found in symptompresenting depressive patients. Male and female f344ntac rats and b6c3f1n mice were administered tetrabromobisphenol a purity of greater than 99% in corn oil by gavage for 3 months, and male and female wistar han crl.
A laboratory rat or lab rat is a rat of the species rattus norvegicus domestica which is bred and. Differential effects of aging on fluid intake in response. To this end, we developed a cx3cr1dtr transgenic wistar rat with a diphtheria toxin receptor. Research open access metabolic syndrome markers in.
Laboratory rats introduction origin and development. Hepatoprotective potential of sargassum muticum against. Toxic effect of lead on kidney function in rat wistar. Clinical chemistry reference database for wistar rats and c57bl6 mice olaf boehm1,a, berndt zur2,a, alexander koch1, nguyen tran1, rainer freyenhagen1, matthias hartmann3 and kai zacharowski1,b, 1department of anaesthesiology, heinrich heine university medical school, d40225 du. As controls for the shr, most workers have used normotensive descendants of wistar rats from the colony in kyoto from which the shr strain was derived wistar kyoto rats. The survey, performed at the 10th generation of backcrossing, showed that wistar fatty rats fafa, a congenic strain of wky, developed obesity and obesityrelated features, such as hyperinsulinemia and hyperlipemia, in the same manner as zucker fatty rats. Pdf induction of haematological and lipid profile changes by. The wistar rat, wistar hannover wistar han rat, and wistar unilever wu rat are outbred rat strains, while the wistar kyoto and wistar furth rats. Panchala, a department of pharmacology, institute of pharmacy, nirma university, sarkhej. The methanolic extract of sargassum muticum mesm plays a hepatoprotective role in streptozotocin.
The aim of this study is to scientifically determine if the aqueous leave extracts of azadirachta indica has wound healing abilities. Biochemical evaluation of silver nanoparticles in wistar rats. The phytochemical screening was carried out on the methanol extract. Spontaneous nonthymic t cell lymphomas in young wistar. This is because adobe, the original creator of the pdf format, actually still owns. To see the toxicopathological changes after multiple exposure to acetamiprid. If the image photo is included then we should be careful which pages redirect to this article. Animals were kept under standard laboratory conditions 12 hr12 hr. Experimental model of heterotopic ossification in wistar rats. Wistar rats were exposed for 2 yr to diesel engine exhaust, carbon black printex 90, degussa, fr.
The zucker fatty rat as a genetic model of obesity and hypertension pdf. Aoues 2 1departement of biotechnology, faculty of sciences, university of mostaganem 27000, algeria. International journal of toxicology differences in rat. Ratmouse default values rat default values subchronic study chronic study weaning bw water intake water factor. Anticataractogenic effect of hesperidin in galactose. A new genetically obesehyperglycemic rat wistar fatty. Clinical chemistry reference database for wistar rats and. This article is an openaccess article which was selected by an inhouse editor.
The wistar bloodline has contributed more strains of rats than any other line. In the present study virgin wistar female rats served as experimental animals. Wistar rats male, 34 months, 250300 g were housed six animals per cage. Aged munich wistar mw rats, like some other rat strains, develop some features characteristic of aging humans 1618 in that. These rats have been used extensively in physiological. Since oxidative stress is implicated in the pathogenesis of liver diseases, this study was carried out to evaluate the hepatoprotective, hematoprotective and hypolipidemic effects of pleurotus ostreatus oyster mushroom in carbon tetrachloride ccl4 induced liver injury in wistar rats. Most are derived from the albino wistar rat, which is still widely used. The spontaneously hypertensive rat shr initially bred in kyoto is the most widely studied animal model of essential hypertension. Clinical chemistry reference database for wistar rats and c57bl6 mice olaf boehm1,a, berndt zur2,a, alexander koch1, nguyen tran1, rainer freyenhagen1, matthias hartmann3 and kai zacharowski1,b. Nephroprotective effect of sonchus oleraceus extract. A biodistribution study of y in male and female wistar rats was carried out in whole blood, liver, kidneys, intestine, heart, brain, lungs and spleen after 28 days of repeated oral treatment. In this study, we therefore aimed to determine how microglia contribute to shortterm memory in healthy adults. The one problem is that there arent very many free pdf editors.
The rats were divided into five groups of six rats. Effects of nori and wakameenriched meats with or without supplementary cholesterol on arylesterase activity, lipaemia and lipoproteinaemia in growing wistar rats volume 106 issue 10. This study was conducted to determine the mechanisms implicated in the beneficial effects of apple polyphenols aps against diet. The clinical research in past decade has reported that most secondgeneration antipsychotics sgas can cause serious metabolic derangement, which substantially increases the risk for type ii diabetes mellitus. Thirty male wistar rats, adult weighing between 120g and 250g were distributed as. Evaluation of the effects of fasting on fertility in adult. Twenty male wistar rats two groups of 10 control and 10 experimental rats of average weight 150200g were used for this study. Not all people looking for information on wistar rats are looking for information on lab rats. The aim of this study was to evaluate the effects of a diet containing gm soybean meal rur on male and female wistar rats.
The body weights, food consumption, hematology, serum biochemistry, organ weight, and histopathological examination were compared between rats. Twenty male wistar rats two groups of 10 control and 10 experimental rats. Pdf toxicological studies on albino wistar rats cotreated with. Biochemical and histopathological studies on female and. Pdf toxicological studies on albino wistar rats coadministered with. Glial remodeling enhances shortterm memory performance in. Roundup ready became the most cultivated genetically modified gm crop in the world. En als het al om outbred wistars zou gaan, dan is het zo dat er enorme.
The folkloric claim of musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. He later established wistar institute in philadelphia that will have a major role in the development of the rat as an important laboratory animal similar to the impact the jackson laboratory had on the development of the laboratory mouse. Authors are also permitted to selfarchive their manuscripts. Differential effects of h2 receptor antagonists on male. Adult wistar rats n 18 females and 26 males were obtained from charles river and maintained on teklad 2020 phytoestrogenfree diet, then paired and monitored for the presence of a. Wistar han list of studies wistar han rats species strain sex route vehicle chemical rats wistar han male and female gavage corn oil pentabromodiphenyl ether mixture de71 technical grade rats wistar han male and female gavage corn oil tetrabromobisphenol a rats wistar han male and female gavage water green tea extract rats wistar. For instance, wistar rats were more susceptible to chronic stressinduced periodontitis than lewis rats. Histopathology of skin and kidney of rat neonates showed marked damage. This particular colony was selected because of a low incidence of hydronephrosis. Anticataractogenic effect of hesperidin in galactoseinduced cataractogenesis in wistar rats. The males were then removed and the dams were housed individually. The animals were made available in the central animal house, gsvm medical college, kanpur, uttar pradesh, india. The age at detection of first glycosuria has varied from 48 to 120 days, with a mean of 67 days. Male wistar rats were randomly divided into control.
Pdf toxicopathological changes on wistar rat after multiple. Variation in normal sodium, potassium, and calcium levels in. Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus dm. A new, spontaneously diabetic syndrome has been recognized in nonobese outbred wistar rats of both sexes. Therefore this work studied the cytoprotective and gastric acid secretory effects of rabeprazole, ranitidine, omeprazole and cimetidine in wistar rats. The fa gene was transferred from the zucker rat m strain to the wistar kyoto wky rat. The wistar bloodline has contributed more strains of rats. Journal of physiology and pathophysiology evaluation of. Adequate studies have been done using proton pump inhibitors and h2receptor antagonist and only few studies for cytoprotective and gastric acid secretions have been done in nigeria. Evaluation of the effects of fasting on fertility in adult male wistar rats. The pilot study first phase used 16 adult male wistar albino rats rattus norvegicus weighing 300350 g, approximately 3 months of age, divided into four groups of 4 rats. This is in addition to the longest survival rate, lower bodyweight compared to sd rats, and lower tumor incidence compared to sd and f344 rats.
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